Decoy cells pdf file

Background bk polyomavirus is one of the common posttransplant viral infections, affecting. Several viruses mediated the emergence of decoy cells, amongst which cytomegalovirus and polyomavirus. Product assortment competition with the decoy e ect anton kleywegt, xinchang wang h. Bkv dna was measured 3, 6, and 12 months after transplantation and whenever decoy cells were detected. The hallmark of the pvbk infection is the presence in the urine of so. The role of decoy cells in urine cytology in detection of polyomavirus infection in post renal transplant patients three species, bk virus, jc virus and simian virus sv40 causes disease in humans. The use of urine cytology to detect the presence of infected decoy cells in the urine has approximately 100% sensitivity for bk virus infection but a low 29%. The decoy cell strategy i cell, which means immunetraining cells has been conceptualized and developed by sorrento scientists utilizing expertise acquired in the. Urinary decoy cell grading and its clinical implications. Urine with large numbers of decoy cells 10cytospin, inflammatory sediments and biopsy proven pvn have been noted to have significantly greater decay in renal function than. Decoy cells are virally infected epithelial cells that can be found in the urine. Pdf bk polyomavirusinfected decoy cells in urine cytology. Exfoliated pyvinfected cells pose diagnostic pitfalls, hence they are termed decoy cells as they may mimic highgrade urothelial carcinoma cells.

The quantitative polymerase chain reaction for bk virus dna in the plasma and in the urine was positive. Each target contains around 200825 decoys, from which all the zhangserver and quark server models have been selected. Ebola virus uses a protein decoy to subvert the host immune response. Ebola virus uses a protein decoy to subvert the host.

The finding of decoy cells in the urine indicates the reactivation of a polyomavirus pv within some epithelial cells of the urinary tract. The protein shares regions with a membrane protein that the. Decoy cells are mostly prevalent in immunocompromised individuals, such as transplant recipients who are treated with immunosuppressive medication in order for their immune system not to reject the foreign transplanted organ. Prospective study of polyomavirus type bk replication and. They can be easily detected in standard papanicolaoustained cytology preparations or with some expertise also in the urine sediment by phase contrast microscopy 12,21,28,31, 41,73,75,82, 95 9697.

Decoy cells are virus infected urothelial cells with a distinct morphology of enlarged nuclei and intranuclear inclusions. All patients with bkn shed abundant polyomavirus inclusion bearing decoy cells in the urine. Pdf urinary decoy cell grading and its clinical implications. Milton stewart school of industrial and systems engineering, georgia institute of technology, atlanta, ga 30332. Reactivation of polyomavirus infection with shedding of infected urothelial cells decoy cells is estimated to occur in 10% to 60% of renal transplant recipients, but clinically significant disease occurs in less than 5%. The clinical features associated with infection of renal transplant patients include asymptomatic infection most common, acute and chronic allograft dysfunction, and hemorrhagic cystitis. Several viruses mediated the emergence of decoy cells, amongst which cytomegalovirus. Pdf background bk polyomavirus is one of the common posttransplant viral infections, affecting. We suggest, however, that a different mechanism may underlie much of the therapeutic action of rituximab in autoimmune diseases. Examination of urine for decoy cells dcs is a useful screening test for polyomavirus pv.